Sprague dawley male rats (56) of uniform body weight and age were randomly divided into seven groups consisting of eight rats in each group. The rats were maintained for a period of 3 weeks for acclimatization and further to evaluate the interaction of atorvastatin with garlic in induced dyslipidaemia. Group 1 was served as plain control, while groups 2 and 3 were fed with high fat and high cholesterol diet throughout the experimental period. Groups 4, 5, 6 and 7 received 1% (100% dose), 0.5% (50% dose), 0.25% (25% dose) and 0.75% (75% dose) fresh garlic w/w in feed, respectively in addition to the high fat and high cholesterol diet and administered with 10 (100% dose), 5 (100% dose), 7.5 (100% dose) and 2.5 (25% dose) mg/kg atorvastatin, respectively, while group 3 served as atorvastatin control, which received 10 mg/kg atorvastatin per day orally for 12 weeks. The activity of AST and SOD, and concentration of TBARS and reduced glutathione (GSH) were estimated in liver, which revealed significant (p<0.05) alterations in treated groups when compared to normal control. Liver was also subjected for histopathology and electron microscopy. There was moderate to severe damage on histopathology and mitochondrial damage on transmission electron microscopy in groups 4 and 5. From this study, it can be concluded that the combination of garlic in high dose proportion and atorvastatin in low dose proportion exhibited better safety, while high dose of atorvastatin proved toxic.
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